| Pair Name | Beta-Elemene, Temozolomide | ||
| Phytochemical Name | Beta-Elemene (PubChem CID: 6918391 ) | ||
| Anticancer drug Name | Temozolomide (PubChem CID: 5394 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Beta-Elemene, Temozolomide | |||
| Disease Info | [ICD-11: 2A00] | Glioblastoma multiforme | Investigative | |
| Gene Regulation | Down-regulation | Expression | AKT1 | hsa207 |
| Down-regulation | Phosphorylation | ATM | hsa472 | |
| Down-regulation | Expression | MAPK3 | hsa5595 | |
| Down-regulation | Expression | H2AX | hsa3014 | |
| In Vitro Model | U-87MG ATCC | Glioblastoma | Homo sapiens (Human) | CVCL_0022 |
| T98G | Glioblastoma | Homo sapiens (Human) | CVCL_0556 | |
| U-251MG | Astrocytoma | Homo sapiens (Human) | CVCL_0021 | |
| LN-229 | Glioblastoma | Homo sapiens (Human) | CVCL_0393 | |
| C6 | Rat malignant glioma | Rattus norvegicus (Rat) | CVCL_0194 | |
| Result | These results revealed that β-elemene could significantly increase the radiosensitivity and chemosensitivity of GBM. β-elemene may be used as a potential drug in combination with the radiotherapy and chemotherapy of GBM | |||
| No. | Title | Href |
|---|---|---|
| 1 | β-elemene enhances both radiosensitivity and chemosensitivity of glioblastoma cells through the inhibition of the ATM signaling pathway. Oncol Rep. 2015 Aug;34(2):943-51. doi: 10.3892/or.2015.4050. | Click |
